blinds facing open from any position

vs UTG we can use same as vs MP

Minimum ~4% blind defense strategy heads-up against an MP (20%) open-raise
The minimum 4% defense is covered by:

• 3-bet {KK+} for value together with 20% of "OOP 3-bet air list"
• Flat {QQ,AK}
• This gives ~4% total defense

Alternatively

• 3-bet {QQ+,AK} for value together with 50% of "OOP 3-bet air list"
• This gives 6% total defense

Minimum ~7% blind defense strategy heads-up against a CO (25%) open-raise
The minimum 7% blind defense is covered by:

• 3-bet {QQ+,AK} for value together with 50% of "OOP 3-bet air list"
• Flat {JJ-TT,AQ}
• This gives ~8% total defense

Minimum ~16% blind defense strategy heads-up against a button (35%) open-raise
The minimum 16% blind defense is covered by:

• 3-bet {TT+,AQ} for value together with 100% of "OOP 3-bet air list"
• Flat the whole "OOP flat list": {99-77,AJs-ATs,AJo,KTs+,KQo,QJs,JTs} =70 combos
• This gives ~17% total defense

Cliffs: its very hard to exploit blinds from EP, so you shouldnt worry too much about defense.

facing 3bet OOP // facing open IP

optimal strategy pairs for various open-ranges OOP (Alice), together with Bob's lists of 3-bet-bluff hands and flatting hands IP:

Alice opens 15%: Bob plays 15.8% (with 3-bet% =3.6%)
Alice opens 20%: Bob plays 17.0% (with 3-bet% =5.3%)
Alice opens 25%: Bob plays 19.2% (with 3-bet% =8.7%)
Alice opens 30%: Bob plays 19.5% (with 3-bet% =9.4%)
Alice opens 35%: Bob plays 20.3% (with 3-bet% =10.2%)
Alice opens 40%: Bob plays 20.3% (with 3-bet% =10.2%)

Internet on opening bet sizes

Secondly the people behind you. If you have bit nits who fold for small amounts, just minraise 100% of cutoffs and button and collect all the blinds. If you have loose passive fish behind, you want to raise bigger, reason should be obvious. And thirdly your hand strength. In general you shouldn't correlate hand strength to bet size in a predictable manner, but sometimes, especially with fish behind, you should do it. Fish in the BB, you are CO with KK? Jack it up to 4bb. You are SB with 84s? Just minraise.